Steven M Holland Selected Research

Pneumonia (Pneumonitis)

1/2023	Case report: Discovery of a de novo FAM111B pathogenic variant in a patient with an APECED-like clinical phenotype.
1/2022	Interpretation of Dihydrorhodamine-1,2,3 Flow Cytometry in Chronic Granulomatous Disease: an Atypical Exemplar.
10/2021	Neutralizing type-I interferon autoantibodies are associated with delayed viral clearance and intensive care unit admission in patients with COVID-19.
1/2021	Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1.
1/2021	Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
1/2021	Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine.
1/2021	SARS-CoV-2 Spike Protein-Directed Monoclonal Antibodies May Ameliorate COVID-19 Complications in APECED Patients.
10/2020	Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
1/2019	Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance.
5/2012	Successful use of extracorporeal membrane oxygenation for acute respiratory failure in a patient with chronic granulomatous disease.

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Steven M Holland Research Topics

Disease

107	Infections 05/2024 - 05/2002
52	Chronic Granulomatous Disease 12/2023 - 03/2002
27	Job Syndrome (Hyper-IgE Syndrome) 10/2020 - 12/2004
21	Neoplasms (Cancer) 05/2024 - 02/2004
21	Pneumonia (Pneumonitis) 01/2023 - 02/2004
17	Inflammation (Inflammations) 03/2024 - 03/2002
17	GATA2 Deficiency 10/2023 - 09/2011
16	Mycoses (Diseases, Fungus) 03/2024 - 06/2003
15	COVID-19 03/2024 - 10/2020
14	Eczema 09/2017 - 01/2004
11	Reinfection 09/2017 - 03/2003
8	Pulmonary Alveolar Proteinosis 10/2022 - 02/2010
8	Virus Diseases (Viral Diseases) 01/2022 - 11/2009
8	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2021 - 12/2010
7	Opportunistic Infections (Opportunistic Infection) 03/2024 - 12/2010
7	Neutropenia 01/2024 - 12/2009
7	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2023 - 03/2010
7	Coccidioidomycosis 01/2021 - 09/2009
7	Primary Immunodeficiency Diseases 01/2020 - 05/2008
7	Tuberculosis (Tuberculoses) 01/2019 - 04/2006
6	Lymphopenia (Lymphocytopenia) 01/2024 - 01/2012
6	Immune System Diseases (Immune Disorders) 01/2024 - 09/2002
6	Bacterial Infections (Bacterial Infection) 01/2024 - 06/2003
6	Eosinophilia 05/2018 - 01/2004
6	Abscess 01/2018 - 12/2004
6	Colitis 01/2017 - 12/2010
5	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 01/2023 - 08/2016
5	Cryptococcosis 10/2022 - 03/2014
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 02/2014
5	Disease Progression 01/2022 - 12/2009
5	Chronic Mucocutaneous Candidiasis 01/2022 - 08/2010
5	Exanthema (Rash) 01/2012 - 06/2003
5	Scoliosis 05/2009 - 11/2005
4	Lung Diseases (Lung Disease) 05/2024 - 10/2006
4	Aspergillosis 05/2024 - 04/2004
4	Thymoma (Thymic Carcinoma) 03/2024 - 12/2010
4	Periodontitis 03/2024 - 03/2014
4	Lymphadenopathy 10/2023 - 04/2004
4	Bronchiectasis 01/2023 - 12/2008
4	Nocardia Infections 10/2022 - 08/2002
4	Cryptococcal Meningitis 10/2022 - 08/2012
4	Cytopenia 01/2022 - 02/2010
4	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 02/2014
4	type 1 Autoimmune polyendocrinopathy syndrome 01/2021 - 12/2010
4	Inborn Genetic Diseases (Disease, Hereditary) 09/2017 - 01/2007
4	Hypertension (High Blood Pressure) 12/2014 - 10/2002
4	Autoimmune Diseases (Autoimmune Disease) 12/2013 - 02/2004
4	Dermatitis 01/2012 - 03/2004
3	Anaphylaxis (Anaphylactic Shock) 03/2024 - 12/2013
3	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2024 - 11/2010
3	Lymphoma (Lymphomas) 01/2023 - 12/2004
3	Candidiasis (Moniliasis) 01/2022 - 12/2010

Drug/Important Bio-Agent (IBA)

45	AutoantibodiesIBA 03/2024 - 10/2005
32	Immunoglobulin E (IgE)IBA 10/2020 - 01/2004
28	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2022 - 03/2002
22	CytokinesIBA 09/2023 - 02/2006
21	InterferonsIBA 12/2023 - 08/2005
17	Interferon-gamma (Interferon, gamma)IBA 01/2024 - 08/2002
17	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2023 - 04/2003
16	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2004
15	Anti-Bacterial Agents (Antibiotics)IBA 05/2024 - 03/2003
15	Interleukin-12 (IL 12)IBA 03/2024 - 09/2002
13	Superoxides (Superoxide)IBA 01/2024 - 03/2002
13	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 04/2016 - 03/2002
11	NADP (NADPH)IBA 12/2023 - 03/2011
11	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 10/2022 - 02/2010
10	AntibodiesIBA 01/2024 - 12/2010
10	Oxidoreductases (Dehydrogenase)IBA 12/2023 - 10/2003
8	Immunoglobulin G (IgG)IBA 10/2023 - 06/2008
7	Biomarkers (Surrogate Marker)IBA 03/2024 - 02/2006
7	Immunoglobulins (Immunoglobulin)IBA 01/2024 - 02/2010
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021 - 10/2003
7	STAT1 Transcription FactorIBA 01/2021 - 09/2002
7	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2018 - 12/2008
6	Messenger RNA (mRNA)IBA 03/2024 - 01/2017
6	VaccinesIBA 03/2024 - 04/2014
6	AntigensIBA 03/2024 - 04/2008
6	Oxidants (Oxidizing Agents)IBA 01/2022 - 03/2002
6	GATA2 Transcription FactorIBA 01/2022 - 04/2013
5	Interleukin-23 (Interleukin 23)IBA 03/2024 - 03/2014
5	Amphotericin B (Amphotericin)FDA LinkGeneric 01/2022 - 02/2006
5	Busulfan (Busulfex)FDA Link 01/2022 - 12/2014
5	Interferon gamma ReceptorIBA 08/2013 - 09/2004
4	Interferon Type IIBA 12/2023 - 01/2021
4	NF-kappa B (NF-kB)IBA 01/2016 - 02/2004
4	Matrix Metalloproteinases (MMPs)IBA 09/2015 - 06/2003
4	EnzymesIBA 01/2015 - 04/2003
4	DNA (Deoxyribonucleic Acid)IBA 07/2013 - 04/2004
3	LactamsIBA 05/2024 - 10/2021
3	mRNA VaccinesIBA 03/2024 - 11/2021
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2022 - 01/2020
3	interleukin-21 (interleukin 21)IBA 01/2022 - 07/2014

Therapy/Procedure

36	Therapeutics 05/2024 - 03/2003
15	Transplantation 11/2022 - 05/2004
13	Hematopoietic Stem Cell Transplantation 01/2022 - 06/2011
6	Immunotherapy 01/2023 - 02/2006
5	Cell Transplantation 04/2022 - 07/2019
5	Stem Cell Transplantation 01/2022 - 10/2003
5	Drug Therapy (Chemotherapy) 01/2017 - 12/2004
4	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/2020 - 02/2015